FITC标记的ATP结合蛋白家族6抗体
产品名称： FITC标记的ATP结合蛋白家族6抗体
英文名称： Anti-ABCB6/FITC
产品编号： HZ-1224R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-ABCB6/FITC Conjugated antibody
FITC标记的ATP结合蛋白家族6抗体
| 英文名称 | Anti-ABCB6/FITC |
| 中文名称 | FITC标记的ATP结合蛋白家族6抗体 |
| 别 名 | ABC; ABC14; EST45597; ABC 14; ABC-14; ABCB 6; ABCB-6; PRP; UMAT; ABC transporter umat; MTABC3; Mt-ABC transporter 3; umat; Mitochondrial precursor; Mitochondrial ABC transporter 3; Mitochondrial abc protein 3; ATP-binding cassette, sub-family B, member 6, mitochondrial precursor; ATP binding cassette, sub family B (MDR/TAP), member 6; P glycoprotein related protein; Abcb6; ABCB6_HUMAN; ATP binding cassette sub family B member 6, mitochondrial precursor; ATP-binding cassette sub-family B member 6; Mitochondrial ABC transporter 3; mitochondrial; Mt ABC transporter 3; P-glycoprotein-related protein; Ubiquitously-expressed mammalian ABC half transporter; UMAT; Ubiquitously expressed mammalian ABC half transporter. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 信号转导 新陈代谢 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 94kDa |
| 细胞定位 | 细胞膜 线粒体 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ABCB6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. Function: Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis Subunit: Homodimer. Subcellular Location: Cell membrane. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Tissue Specificity: Widely expressed. High expression is detected in the retinal epithelium. DISEASE: Microphthalmia, isolated, with coloboma, 7 (MCOPCB7) [MIM:614497]: A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain. Database links: Entrez Gene: 10058 Human Entrez Gene: 74104 Mouse Entrez Gene: 140669 Rat Omim: 605452 Human SwissProt: Q9NP58 Human SwissProt: Q9DC29 Mouse SwissProt: O70595 Rat SwissProt: Q9Z1S2 Rat Unigene: 107911 Human Unigene: 28663 Mouse Unigene: 54408 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ABCB6蛋白对于红细胞携带氧，肝细胞破坏毒素以及细胞从摄取营养物质后排放能量方面发挥重要的作用 |
由该基因编码的膜相关蛋白是ATP结合盒（ABC）转运蛋白超家族的成员。ABC蛋白通过胞外膜和胞内膜运输各种分子。ABC基因分为七个不同亚家族（ABC1、MDR/TAP、MRP、ALD、OABP、GCN20、White）。该蛋白是MDR/TAP亚家族的成员。MDR/TAP亚家族成员参与多药耐药性和抗原呈递。这种半转运蛋白可能在线粒体功能中发挥作用。该基因定位于2q26，被认为是致死性新生儿代谢综合征（一种线粒体功能紊乱）的候选基因。