FITC标记的剪切及多聚腺苷酸化特异因子蛋白1抗体
产品名称： FITC标记的剪切及多聚腺苷酸化特异因子蛋白1抗体
英文名称： Anti-CPSF1/FITC
产品编号： HZ-14035R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CPSF1/FITC Conjugated antibody
FITC标记的剪切及多聚腺苷酸化特异因子蛋白1抗体
| 英文名称 | Anti-CPSF1/FITC |
| 中文名称 | FITC标记的剪切及多聚腺苷酸化特异因子蛋白1抗体 |
| 别 名 | Cleavage and polyadenylation specificity factor 160 kDa subunit; Cleavage and polyadenylation specificity factor subunit 1; CPSF 160 kDa subunit; CPSF160; HSU37012; P/cl.18. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 161kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CPSF1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008] Function: CPSF1 (Cleavage and polyadenylation specificity factor subunit 1) is a component of the cleavage and polyadenylation specificity factor (CPSF) complex. It plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. Subcellular Location: Nucleus, nucleoplasm. Post-translational modifications: The N-terminus is blocked. Similarity: Belongs to the CPSF1 family. Database links: Entrez Gene: 29894 Human Entrez Gene: 94230 Mouse Entrez Gene: 366952 Rat Omim: 606027 Human SwissProt: Q10570 Human SwissProt: Q9EPU4 Mouse SwissProt: B5DEL2 Rat Unigene: 493202 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
裂解和聚腺苷酸化特异因子（CPSF）是一个多亚基复合物，在mRNA前体的3质粒加工中起着核心作用。CPSF识别前mRNA中的AAUAAA信号，并与其他蛋白相互作用，从而促进RNA裂解和poly(A)合成。CPSF1是CPSF复合物的最大亚基（Murthy and Mangle，1995 [PubMed 7590244 ]）。